ODCs

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8 OMIM references -
6 associated genes
12 signs/symptoms

PROTEIN INTERACTIONS: 3
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
10 signs/symptoms

Familial melanoma

Hereditary cerebral hemorrhage with amyloidosis, Iowa type


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	CDK4 CDKN2B CDKN2D	(0.56) (0.56) (0.56)	APP APP APP

Citations in the biomedical literature:

Familial melanoma		Hereditary cerebral hemorrhage with amyloidosis, Iowa type
	Synonym(s): (no synonyms)		Synonym(s): - HCHWA, Iowa type

	Classification (Orphanet): - Rare eye disease - Rare genetic disease - Rare oncologic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease - Rare systemic or rheumatologic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 8 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Familial melanoma		Hereditary cerebral hemorrhage with amyloidosis, Iowa type
	Very frequent - Capillary hemangioma / nevus / naevus flammeus / port-wine stain - Melanoma Frequent - Anomalies of the lymphatic system - Dry / squaly skin / exfoliation - Excessive freckling - Hair and scalp anomalies Occasional - Breast neoplasm / tumor / carcinoma / cancer - Estomach / gastric neoplasm / tumor / carcinoma / cancer - Extrapyramidal syndrome - Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer - Retinopathy		Very frequent - Abnormal gait - Cerebral vascular anomalies - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Intracranial / cerebral / meningeal hemorrhage - Myoclonus / fasciculations - Psychic / behavioural troubles - Psychic / psychomotor regression / dementia / intellectual decline - Transient cerebral ischemia / stroke - Troubles of memory / amnesia / hypermnesia